Prematurely aged stem cells in pSS

Prematurely aged stem cells in pSS

Research Highlight in Nature Reviews Rheumatology.

“Over the past 25 years, theories around the cause of salivary gland hypofunction, a major clinical manifestation of primary Sjögren syndrome (pSS), have steadily moved away from inflammation towards other possible factors, including salivary gland stem cells. Now, in the first study of its kind, salivary gland stem cells from patients with pSS have been isolated and characterized, revealing a prematurely aged, senescent phenotype.”

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